pentobarbital will minimize the extent or impact of fedratinib by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Prevent or Use Alternate Drug. Result of coadministering a powerful CYP3A4 inducer with fedratinib hasn't been studied.

pentobarbital will lower the extent or influence of nitrendipine by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Insignificant/Importance Unidentified.

Reserve concomitant prescribing of those drugs in sufferers for whom other treatment possibilities are insufficient. Limit dosages and durations towards the bare minimum expected. Observe intently for signs of respiratory depression and sedation.

pentobarbital will decrease the extent or effect of tamoxifen by affecting hepatic enzyme CYP2C9/10 metabolism. Use Warning/Keep an eye on.

pentobarbital will reduce the level or result of losartan by influencing hepatic enzyme CYP2C9/ten metabolism. Slight/Importance Not known.

pentobarbital will lower the extent or impact of stiripentol by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Stay away from or Use Alternate Drug. If not able to prevent coadministration of stiripentol with potent CYP3A4 inducers, raise stiripentol dose.

pentobarbital will reduce the extent or influence of irinotecan liposomal by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Warning/Keep an eye on.

pentobarbital will lessen the extent or influence of cyclosporine by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Observe.

pentobarbital will decrease the extent or outcome of darunavir by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Use Caution/Observe.

pentobarbital will reduce the extent or result of vincristine by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Minimal/Significance Mysterious.

Observe Intently (two)pentobarbital will lower the level or outcome of buprenorphine, very long-acting injection by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Keep track of Carefully. Sufferers who transfer to buprenorphine prolonged-acting injection from transmucosal buprenorphine coadministered with CYP3A4 inducers must be monitored to make certain buprenorphine plasma degrees are enough.

pentobarbital will lower the level or outcome of colchicine by affecting hepatic/intestinal enzyme read more CYP3A4 metabolism. Use Caution/Keep an eye on.

pentobarbital will lower the extent or impact of etravirine by affecting hepatic enzyme CYP2C9/ten metabolism. Use Caution/Observe.

Therapy ought to be administered with warning, if at all, to patients that are mentally frustrated, have suicidal tendencies, or historical past of drug abuse